01 - Whisk buttermilk with salt, garlic powder, onion powder, cayenne, and black pepper in a large bowl. Submerge chicken pieces completely in the marinade. Cover bowl and refrigerate minimum 2 hours, preferably overnight for optimal flavor penetration.
02 - Combine flour, paprika, salt, black pepper, cayenne, and baking powder in a separate bowl. Whisk thoroughly to evenly distribute spices throughout the flour mixture.
03 - Remove chicken from marinade, allowing excess liquid to drip off. Dredge each piece in flour mixture, pressing firmly to ensure thick, even coating. Arrange coated pieces on wire rack and rest 10 minutes to set the coating.
04 - Pour vegetable oil into deep fryer or heavy-bottomed pot. Heat to 350°F, maintaining temperature throughout frying process.
05 - Carefully lower chicken pieces into hot oil in small batches. Fry 12-15 minutes, turning occasionally, until golden brown and crisp with internal temperature reaching 165°F.
06 - Transfer fried chicken to wire rack or paper towels to drain excess oil. Let rest 5 minutes before serving to allow juices to redistribute.